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Utah eye researcher targets mutated DNA
Feb 08, 2013 | 914 views | 0 0 comments | 5 5 recommendations | email to a friend | print
Yingbin Fu, a Moran researcher and assistant professor of Ophthalmology and Visual Science at the University of Utah.
Courtesy photo
Yingbin Fu, a Moran researcher and assistant professor of Ophthalmology and Visual Science at the University of Utah. Courtesy photo
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SALT LAKE CITY – A goal to permanently correct disease-associated mutations in the eye by way of targeting DNA sequences is earning one University of Utah professor national attention.

Yingbin Fu, a Moran researcher and assistant professor of Ophthalmology and Visual Science at the University of Utah at the John A. Moran Eye Center has been selected as one of 10 winners by the National Eye Institute (NEI), part of the National Institutes of Health, according to a press release from Love Communications in Salt Lake City. That release goes on as follows:

Fu is one of 10 winners of the Audacious Goals Challenge, a nationwide competition for compelling ideas to advance vision and science.

His “audacious” goal – Precise Gene Editing In Vivo – aims to permanently correct disease-associated mutations in a patient through the use of molecules specially designed to target mutated DNA sequences that can be delivered safely and efficiently into the eye, which would lead to an enormous step in the prevention and cure of human ocular diseases.

 “If this goal is achieved, the impact would be enormous in the prevention and cure of human diseases,” Fu said. “As we enter the era of personalized medicine, it has become more and more practical to sequence a person’s genome at low cost, which makes it possible for us to catch disease-causing mutations early and before the onset of disease.”

 Dr. Fu’s vision is to correct these “bad guys” using highly efficient and safe molecular scissors to prevent disease development. Of course, it can also be used to treat disease in the early and intermediate stages. Beyond eye disease, this strategy could also be applied to the genetic component of virtually any human disease, whether inherited or resulting from cellular responses to environmental stresses.

 The NEI Challenge to Identify Audacious Goals in Vision Research and Blindness Rehabilitation is part of a government-wide effort to bring the best ideas and top talent to bear on our nation’s most pressing challenges. Entries were reviewed by experts on the basis of relevance to the NEI mission and whether the idea is bold, daring, unconventional, or exceptionally innovative; broad in scope; and potentially attainable in about 10 years.

 “It is an incredible honor for the Moran Eye Center for Dr. Fu to receive this prestigious and well-deserved award,” said Dr. Randall J. Olson, chairman and CEO of the John A. Moran Eye Center. “Dr. Fu’s work gives hope to the idea that diseased optic pathways can be restored to function as intended. This work is truly ‘audacious’ in the best sense of the word and revolutionizes this area of science.”

 The challenge sought ideas that support the NEI mission to conduct and support research and other programs aimed at reducing the burden of vision disorders and disease worldwide. Prize competition entries were solicited not only from experts in vision research but from anyone in the private, government, and nonprofit sectors, including scientists, engineers, health care providers, inventors, and entrepreneurs, as well as the general public.

 “We didn’t know what to expect when we issued this challenge,” said Richard S. Fisher, Ph.D., director of NEI’s Office of Program Planning and Analysis, which is spearheading the initiative. “Surprisingly, nearly half of the submissions we received came from people who had never been funded by NIH, which demonstrated that we captured the attention of a wide audience throughout the U.S. We invited anyone with an interest in vision research to submit an idea that began with the phrase, ‘It would be fantastic if…’ and in fact, we received many truly audacious ideas.”

 Within a three-month period, 476 entries were submitted from people across the United States, including Puerto Rico. Topics ranged from regenerative medicine and stem cells to neuroscience, genetics, drug development, and artificial vision and prosthetics.

 In addition to Fu, winners include doctors and researchers from the University of California, Santa Barbara; Oregon Health and Science University; University of Alabama: the Washington University School of Medicine and The Retina Institute in St. Louis, Missouri; Vanderbilt University; University of Michigan; Capital Region Retina, PLLC, in Albany, New York; University of Washington; and Massachusetts Eye and Ear Infirmary at Harvard Medical School.

Fu will present his ideas at the NEI Audacious Goals Development Meeting, which will include about 200 vision researchers, patient advocates, ophthalmologists and optometrists from the U.S. and abroad. His ideas will be discussed intensively among other winners’ for further expansion, development, and refinement. Following the meeting, NEI staff and members of the National Advisory Eye Council will finalize and publish a set of the most compelling audacious goals for the institute and the broader vision research community to pursue over the next decade.

“The selection of the winning entries marks the true starting point for NEI’s Audacious Goals initiative,” said Dr. Fisher. “We are now at the point where some of the world’s most prominent vision experts can discuss these ideas in-depth, establish a set of audacious goals, and weigh in on how we can realize those goals.”

 For more information about the challenge, visit the Audacious Goals website at http://www.nei.nih.gov/challenge.

 For additional information about the Moran Eye Center, visit http://healthcare.utah.edu/moran.

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